Monday, July 13, 2020

World’s First 3D Vascularised Heart

Recently  researchers have “printed” the world’s first 3D vascularised engineered heart using a patient’s own cells and biological materials in a major breakthrough of technology.

Until now, scientists in regenerative medicine a field positioned at the crossroads of biology and technology have been successful in printing only simple tissues without blood vessels. This is the first time anyone anywhere has successfully engineered and printed an entire heart replete with cells, blood vessels, ventricles and chambers.

Heart disease is the leading cause of death among both men and women in the world. Heart transplantation is currently the only treatment available to patients with end-stage heart failure. Given the dire shortage of heart donors, the need to develop new approaches to regenerate the diseased heart is urgent.

This heart is made from human cells and patient-specific biological materials. In their process these materials serve as the bioinks, substances made of sugars and proteins that can be used for 3D printing of complex tissue models. People have managed to 3D-print the structure of a heart in the past, but not with cells or with blood vessels. Their  results demonstrate the potential of their approach for engineering personalized tissue and organ replacement in the future.

At this stage, our 3D heart is small, the size of a rabbit’s heart, accordingly to the researchers.

For the research, a biopsy of fatty tissue was taken from patients. The cellular and a-cellular materials of the tissue were then separated. While the cells were reprogrammed to become pluripotent stem cells, the extracellular matrix (ECM), a three-dimensional network of extracellular macromolecules such as collagen and glycoproteins, were processed into a personalized hydrogel that served as the printing “ink.”

After being mixed with the hydrogel, the cells were efficiently differentiated to cardiac or endothelial cells to create patient-specific, immune-compatible cardiac patches with blood vessels and, subsequently, an entire heart.

According to the researchers, the use of “native” patient-specific materials is crucial to successfully engineering tissues and organs.

The biocompatibility of engineered materials is crucial to eliminating the risk of implant rejection, which jeopardizes the success of such treatments. Ideally, the biomaterial should possess the same biochemical, mechanical and topographical properties of the patient’s own tissues. Here, they can report a simple approach to 3D-printed thick, vascularized and perfusable cardiac tissues that completely match the immunological, cellular, biochemical and anatomical properties of the patient.

The researchers are now planning on culturing the printed hearts in the lab and “teaching them to behave” like hearts. They then plan to transplant the 3D-printed heart in animal models.

Maybe, in ten years, there will be organ printers in the finest hospitals around the world, and these procedures will be conducted routinely.

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